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KMID : 1134120160190030324
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Journal of Breast Cancer
2016 Volume.19 No. 3 p.324 ~ p.329
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Ductal Breast Carcinoma Metastatic to the Stomach Resembling Primary Linitis Plastica in a Male Patient
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Biagio Ricciuti
Giulia Costanza Leonardi
Noemi Ravaioli
Andrea De Giglio
Marta Brambilla
Enrico Prosperi
Franca Ribacchi
Marialuisa Meacci
Lucio Crino
Daniele Maiettini
Rita Chiari
Giulio Metro
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Abstract
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Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation. Moreover, we propose a immunohistochemical panel of selected antibodies including those for cytokeratin 20, cytokeratin 7, estrogen receptor, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15, and GATA binding protein 3 for an accurate differential diagnosis.
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KEYWORD
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Biomarkers, Breast neoplasms, Human epidermal growth factor receptor 2, Linitis plastica, Neoplasm metastasis
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